| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/17/2025 | ATH | Anderson,Ty | Traded away | TOR | | After |
| 3/17/2025 | ATH | France,T | Acquired via trade | TOR | | After |
| 3/17/2025 | ATH | MacIver | Acquired via trade | TBR | | After |
| 3/17/2025 | ATH | Moniak | Traded away | MIN | | After |
| 3/17/2025 | BAL | Bader | Traded away | MIA | | After |
| 3/17/2025 | BAL | Cease | Acquired via trade | NYY | | After |
| 3/17/2025 | BAL | Freeman,T | Traded away | NYY | | After |
| 3/17/2025 | BAL | Holmes,C | Acquired via trade | MIA | | After |
| 3/17/2025 | BOS | Narvaez,C | Traded away | TEX | | After |
| 3/17/2025 | CLE | Alcala | Acquired via trade | HOU | | After |
| 3/17/2025 | CLE | Bello | Traded away | MIA | | After |
| 3/17/2025 | CLE | Diaz,El | Acquired via trade | TEX | | After |
| 3/17/2025 | CLE | Freeman,F | Traded away | HOU | | After |
| 3/17/2025 | CLE | Gusto | Acquired via trade | SEA | | After |
| 3/17/2025 | CLE | Hart | Acquired via trade | SEA | | After |
| 3/17/2025 | CLE | Huff | Acquired via trade | HOU | | After |
| 3/17/2025 | CLE | Hurter | Traded away | TEX | | After |
| 3/17/2025 | CLE | Jimenez | Traded away | TEX | | After |
| 3/17/2025 | CLE | Kelly,Mi | Traded away | MIA | | After |
| 3/17/2025 | CLE | Kowar | Acquired via trade | NYY | | After |
| 3/17/2025 | CLE | Lindor | Traded away | HOU | | After |
| 3/17/2025 | CLE | Loaisiga | Acquired via trade | TEX | | After |
| 3/17/2025 | CLE | McLain | Acquired via trade | HOU | | After |
| 3/17/2025 | CLE | Montas | Acquired via trade | TEX | | After |
| 3/17/2025 | CLE | Morton | Acquired via trade | MIA | | After |
| 3/17/2025 | CLE | Olson,R | Acquired via trade | HOU | | After |
| 3/17/2025 | CLE | Pozo | Acquired via trade | NYY | | After |
| 3/17/2025 | CLE | Rea | Traded away | SEA | | After |
| 3/17/2025 | CLE | Rolison | Acquired via trade | NYY | | After |
| 3/17/2025 | CLE | Toglia | Acquired via trade | TEX | | After |
| 3/17/2025 | CLE | Tonkin | Acquired via trade | TEX | | After |
| 3/17/2025 | CLE | Vesia | Traded away | HOU | | After |
| 3/17/2025 | CLE | Winker | Acquired via trade | HOU | | After |
| 3/17/2025 | DET | Garcia,Ro | Traded away | HOU | | After |
| 3/17/2025 | DET | Jones,J | Traded away | HOU | | After |
| 3/17/2025 | DET | Loftin | Acquired via trade | HOU | | After |
| 3/17/2025 | DET | Paredes | Acquired via trade | HOU | | After |
| 3/17/2025 | DET | Turner,T | Traded away | HOU | | After |
| 3/17/2025 | HOU | Alcala | Traded away | CLE | | After |
| 3/17/2025 | HOU | Cleavinger | Acquired via trade | MIL | | After |
| 3/17/2025 | HOU | Freeman,F | Acquired via trade | CLE | | After |
| 3/17/2025 | HOU | Garcia,Ro | Acquired via trade | DET | | After |
| 3/17/2025 | HOU | Huff | Traded away | CLE | | After |
| 3/17/2025 | HOU | Jones,J | Acquired via trade | DET | | After |
| 3/17/2025 | HOU | Lindor | Acquired via trade | CLE | | After |
| 3/17/2025 | HOU | Loftin | Traded away | DET | | After |
| 3/17/2025 | HOU | McLain | Traded away | CLE | | After |
| 3/17/2025 | HOU | Olson,R | Traded away | CLE | | After |
| 3/17/2025 | HOU | Paredes | Traded away | DET | | After |
| 3/17/2025 | HOU | Realmuto | Acquired via trade | MIL | | After |
| 3/17/2025 | HOU | Turner,T | Acquired via trade | DET | | After |
| 3/17/2025 | HOU | Uceta | Acquired via trade | MIL | | After |
| 3/17/2025 | HOU | Vesia | Acquired via trade | CLE | | After |
| 3/17/2025 | HOU | Winker | Traded away | CLE | | After |
| 3/17/2025 | HOU | Yates | Traded away | MIL | | After |
| 3/17/2025 | LAA | Acuna,R | Traded away | SDP | | After |
| 3/17/2025 | LAA | Correa | Acquired via trade | SDP | | After |
| 3/17/2025 | MIN | Hatch | Traded away | MIL | | After |
| 3/17/2025 | MIN | Lowe,B | Acquired via trade | MIL | | After |
| 3/17/2025 | MIN | Moniak | Acquired via trade | ATH | | After |
| 3/17/2025 | MIN | Sears | Traded away | PIT | | After |
| 3/17/2025 | MIN | Smith,Cad | Acquired via trade | STL | | After |
| 3/17/2025 | MIN | Vasquez | Traded away | TEX | | After |
| 3/17/2025 | NYY | Cease | Traded away | BAL | | After |
| 3/17/2025 | NYY | Freeman,T | Acquired via trade | BAL | | After |
| 3/17/2025 | NYY | Kowar | Traded away | CLE | | After |
| 3/17/2025 | NYY | Pozo | Traded away | CLE | | After |
| 3/17/2025 | NYY | Rolison | Traded away | CLE | | After |
| 3/17/2025 | SEA | Gusto | Traded away | CLE | | After |
| 3/17/2025 | SEA | Hart | Traded away | CLE | | After |
| 3/17/2025 | SEA | Rea | Acquired via trade | CLE | | After |
| 3/17/2025 | TBR | Canning | Traded away | TOR | | After |
| 3/17/2025 | TBR | MacIver | Traded away | ATH | | After |
| 3/17/2025 | TEX | Allen,L | Acquired via trade | CIN | | After |
| 3/17/2025 | TEX | Devers | Acquired via trade | COL | | After |
| 3/17/2025 | TEX | Diaz,El | Traded away | CLE | | After |
| 3/17/2025 | TEX | Eovaldi | Traded away | COL | | After |
| 3/17/2025 | TEX | Hurter | Acquired via trade | CLE | | After |
| 3/17/2025 | TEX | Jimenez | Acquired via trade | CLE | | After |
| 3/17/2025 | TEX | Loaisiga | Traded away | CLE | | After |
| 3/17/2025 | TEX | Maldonado,M | Traded away | CIN | | After |
| 3/17/2025 | TEX | Montas | Traded away | CLE | | After |
| 3/17/2025 | TEX | Narvaez,C | Acquired via trade | BOS | | After |
| 3/17/2025 | TEX | Perkins,J | Acquired via trade | COL | | After |
| 3/17/2025 | TEX | Tauchman | Acquired via trade | PHI | | After |
| 3/17/2025 | TEX | Toglia | Traded away | CLE | | After |
| 3/17/2025 | TEX | Tonkin | Traded away | CLE | | After |
| 3/17/2025 | TEX | Vasquez | Acquired via trade | MIN | | After |
| 3/17/2025 | TOR | Anderson,Ty | Acquired via trade | ATH | | After |
| 3/17/2025 | TOR | Benintendi | Acquired via trade | CIN | | After |
| 3/17/2025 | TOR | Canning | Acquired via trade | TBR | | After |
| 3/17/2025 | TOR | Contreras,WE | Traded away | CIN | | After |
| 3/17/2025 | TOR | France,T | Traded away | ATH | | After |
| 8/3/2025 | ATH | Blackburn | Demoted to reserve roster | | | Before |
| 8/3/2025 | ATH | Diaz,A | Promoted to active roster | | | Before |
| 8/3/2025 | ATH | Miller,S | Demoted to reserve roster | | | Before |
| 8/3/2025 | ATH | Taylor,Ty | Promoted to active roster | | | Before |
| 8/3/2025 | SEA | Dana | Promoted to active roster | | | Before |
| 8/3/2025 | SEA | Glasnow | Demoted to reserve roster | | | Before |
| 5/1/2026 | BOS | Boushley | Demoted to reserve roster | | | Before |
| 5/1/2026 | BOS | Fletcher | Promoted to active roster | | | Before |
| 5/1/2026 | BOS | Freeman,Co | Demoted to reserve roster | | | Before |
| 5/1/2026 | BOS | Nola,Aa | Demoted to reserve roster | | | Before |
| 5/1/2026 | BOS | Ragans | Promoted to active roster | | | Before |
| 5/1/2026 | BOS | Raley,B | Promoted to active roster | | | Before |
| 5/1/2026 | BOS | Sheehan | Promoted to active roster | | | Before |
| 5/1/2026 | BOS | Waldrep | Demoted to reserve roster | | | Before |
| 5/1/2026 | CHW | Lawrence,J | Promoted to active roster | | | Before |
| 5/1/2026 | CHW | Megill,Tr | Demoted to reserve roster | | | Before |
| 5/1/2026 | CLE | Kowar | Promoted to active roster | | | Before |
| 5/1/2026 | CLE | Perez,W | Demoted to reserve roster | | | Before |
| 5/1/2026 | CLE | Perez,W | Promoted to active roster | | | Before |
| 5/1/2026 | CLE | Rave | Demoted to reserve roster | | | Before |
| 5/1/2026 | CLE | Rave | Promoted to active roster | | | Before |
| 5/1/2026 | CLE | Tonkin | Demoted to reserve roster | | | Before |
| 5/1/2026 | HOU | Bubic | Demoted to reserve roster | | | Before |
| 5/1/2026 | HOU | Darvish | Promoted to active roster | | | Before |
| 5/1/2026 | HOU | Garcia,Ro | Demoted to reserve roster | | | Before |
| 5/1/2026 | HOU | Hernandez,D | Promoted to active roster | | | Before |
| 5/1/2026 | HOU | Kranick | Demoted to reserve roster | | | Before |
| 5/1/2026 | HOU | Marinaccio | Promoted to active roster | | | Before |
| 5/1/2026 | KCR | Mastrobuoni | Promoted to active roster | | | Before |
| 5/1/2026 | KCR | Tellez | Demoted to reserve roster | | | Before |
| 5/1/2026 | MIN | Adam | Demoted to reserve roster | | | Before |
| 5/1/2026 | MIN | Blubaugh | Promoted to active roster | | | Before |
| 5/1/2026 | MIN | Bradley | Demoted to reserve roster | | | Before |
| 5/1/2026 | MIN | Harvey | Promoted to active roster | | | Before |
| 5/1/2026 | MIN | Knizner | Promoted to active roster | | | Before |
| 5/1/2026 | MIN | Mahle | Promoted to active roster | | | Before |
| 5/1/2026 | MIN | Misiorowski | Demoted to reserve roster | | | Before |
| 5/1/2026 | MIN | Reynolds,S | Promoted to active roster | | | Before |
| 5/1/2026 | MIN | Vasil | Demoted to reserve roster | | | Before |
| 5/1/2026 | SEA | Ballesteros | Promoted to active roster | | | Before |
| 5/1/2026 | SEA | Enns | Demoted to reserve roster | | | Before |
| 5/1/2026 | SEA | Glasnow | Promoted to active roster | ATH | | Before |
| 5/1/2026 | SEA | LeMahieu | Demoted to reserve roster | | | Before |
| 5/1/2026 | SEA | Lorenzen | Demoted to reserve roster | ATH | | Before |
| 5/1/2026 | SEA | Selby | Promoted to active roster | | | Before |
| 5/1/2026 | SEA | Urias,L | Promoted to active roster | | | Before |
| 5/1/2026 | SEA | Valdez,E | Demoted to reserve roster | | | Before |